Structural Optimization of 6-aryl Pyridazin3-ones as Novel Potent PDE4 Inhibitors
نویسندگان
چکیده
منابع مشابه
Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases.
Phosphodiesterases (PDEs) are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL was dose and time dependently reduced ...
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ژورنال
عنوان ژورنال: Revista Virtual de Química
سال: 2015
ISSN: 1984-6835
DOI: 10.5935/1984-6835.20150034